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Rab5aQ76L causes VEGFR2 accumulation within enlarged endosomes. Endothelial cells expressing GFP-Rab5aQ79L stimulated with VEGF-A for 0 (A) or 120 (B) min labeled for EEA1 (cyan), VEGFR2 (red) and nuclei (blue). Bar, 10 μm. C, Quantification of VEGFR2-labeled cells overexpressing GFP-Rab5aQ79L after VEGF-A stimulation (*, p<0.05).
