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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Chem Res Toxicol. 2009 Apr;22(4):734–741. doi: 10.1021/tx800479s

Scheme 1.

Scheme 1

Metabolism of 1,3-butadiene (10) to MHBMA (1 and 2) and DHBMA (3)

a. GSH, GSTs; b. γ-glutamyltranspeptidase; c. cysteinylglycine dipeptidase; d. cysteine S-conjugate N-acetyltransferase; EH, epoxide hydrolase; ADH, alcohol dehydrogenase; CR, carbonyl reductase