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. Author manuscript; available in PMC: 2009 Jun 30.
Published in final edited form as: J Biol Chem. 2007 Jun 1;282(30):21712–21719. doi: 10.1074/jbc.M702285200

FIGURE 9. Two-dimensional representation of a proposed three-dimensional model illustrating the synthetic melanocortin NDP-MSH docked inside the hMC4R.

FIGURE 9

Two receptor binding pockets are hypothesized. The first is a predominantly ionic pocket formed by Glu100, Asp122, and Asp126. The second hydrophobic pocket is formed by aromatic residues Trp258, Phe261, and His264 in TM6.