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. 2009 Jun 11;6:8. doi: 10.1186/1742-4933-6-8

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Copyright © 2009 Tarjanyi et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Age-related changes in the cellular composition of the peritoneal lavage (PLF), spleen, and blood of naive (non-immunized) BALB/c mice. Upper panels (A-D) show the changes of the T cell repertoire: (A)T cell percentage, (B) CD44^high(memory): CD62L^high(naive) CD4+ T cell ratio, (C) CD28 expression on CD4+ T cells, and (D) Treg ratio. Lower panels (E-H) summarize the age-related changes in APC composition in the PLF and spleen: (E) conventional B cells, (F) B1 cells (^#In the spleen this cell population is comprised of B1 cells, transitional B cells and marginal zone B cells), (G) macrophages (F4/80+ cells), and (H) dendritic cells (CD11c+ cells). Data represent the mean ± SEM (n = 4–5 mice per group). Values were significantly (p < 0.05) *lower or ^†higher than those measured in the 1-month-old group as indicated.