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Effects of microglial CBR2 activation on the ERK/TNF pathway. Representative western blots (A) and quantification of p-ERK1 (B), p-ERK2 (C) and TNF (D, 34 kD; E, 17 kD) expression at different incubation time points (15–60 min, 0 = medium control group) in LPS-stimulated microglia in the presence or absence of JWH015 (1 μM). JWH015 produced a ERK dephosphorylation (30 min) and TNF reduction (60 min). +p < 0.05 vs. medium control group; *p < 0.05 vs. LPS alone group.
