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. 2008 Jul 24;19(3):365–374. doi: 10.1111/j.1750-3639.2008.00190.x

Figure 1.

Figure 1

Data are average ± standard error of the mean (SEM) concentrations (ng/g) of soluble amyloid (A)β oligomers plotted on linear scale (log scale of the same data in inset) and stratified by Braak stage in six regions of the brain from 14 individuals who died with no cognitive impairment, with mild cognitive impairment (MCI) or with late‐onset Alzheimer's disease (LOAD) (n = 3 for Braak A, n = 7 for Braak B and n = 4 for Braak C); patients were selected from the Alzheimer's Disease Research Center (ADRC) cohort. Two‐way analysis of variance (ANOVA) had P < 0.0001 for Braak stage and brain region as P < 0.05 for interaction between these two terms. We pursued post hoc one‐way ANOVA for each region across Braak stages. In these analyses, middle frontal gyrus (MFG) and superior and middle temporal gyri (SMTG) cortex yielded similar results of P < 0.01 for soluble Aβ oligomers across the three Braak stages; Bonferroni‐corrected repeat paired comparisons had P < 0.01 for Braak stage A vs. Braak stage C for both regions of the brain, but Braak stage B vs. Braak stage C only for MFG. One‐way ANOVA had P < 0.05 for inferior parietal lobule (IPL), but no significant corrected repeat paired comparisons, while one‐way ANOVA for occipital cortex (OC), caudate (Cd) and cerebellum (Cb) had P > 0.05.