. 2009 May 12;30(7):1132–1138. doi: 10.1093/carcin/bgp114

Table IV.

Summary of the relationship between methylation of MMP2, BHLHB4 and p16 with the remaining genes

Gene	No. of genes in the panel^a	Methylation status	No. of primary tumors	Mean number of positive genes in panel	Difference in means (methylated to unmethylated)
Gene	No. of genes in the panel^a	Methylation status	No. of primary tumors	Mean number of positive genes in panel	Difference	95% CI
MMP2	19	+	129	11.5	4.7	3.5–5.9
MMP2	19	−	42	6.8	4.7	3.5–5.9
BHLHB4	16	+	126	10.6	4.2	3.2–5.1
BHLHB4	16	−	45	6.5	4.2	3.2–5.1
p16	16	+	113	10.4	3.5	2.6–4.5
p16	16	−	59	6.9	3.5	2.6–4.5

Genes included in panel were significantly (P < 0.05) and positively associated with MMP2, BHLHB4 or p16.