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. 2009 May 14;30(7):1147–1154. doi: 10.1093/carcin/bgp118

Fig. 1.

Fig. 1.

Schematic diagram and 3D structures of hMYH, hOGG1 and NEIL1. (A) Schematic diagram of the hMYH showing functional domains (left) and 3D structure (right) of MutY from Bacillus stearothermophilus in complex with DNA [Protein Data Bank identifier 1RRQ] (31). The positions of the mutations studied in this work, R260 and H434 are shown and were identified by amino acid sequence alignment of hMYH with BsMutY. Serine501 is outside of the ordered structure. (B) Schematic diagram showing functional domains (left) and 3D structure (right) of hOGG1 in complex with 8oxoG-containing DNA (Protein Data Bank identifier 1EBM) (32). The location of S31P mutation is shown. (C) Schematic diagram of NEIL1 showing functional domains (left) and 3D structure (right) (Protein Data Bank identifier 1TDH) (33) with position of G83 and E181 indicated. For hMYH domains interacting with RPA, MSH6, APE1 and PCNA are indicated. hOGG1 and NEIL1 have a conserved domain (blue) and the NEIL1 C-terminus is necessary for interactions with PCNA, DNA ligase III, DNA polymerase β and XRCC1. The figures are not drawn to scale. Fe-S, Iron-sulfur cluster; H2TH, helix-2-turn-helix motif; HhH, helix-hairpin-helix motif; MTS, mitochondrial targeting signal; NLS, nuclear localization signal; Zn, zinc finger domain.