Fig. 9.

Effects of flufenamate and α-ENaC silencing on HepG2 cell apoptosis (quantified on the basis of a caspase 3/7 enzyme assay). a Apoptosis, under control conditions and in the presence of 2 μM of the apoptosis-inducer camptothecin (used as a positive control here). b, c, Three hundred micromolars flufenamate as well as the silencing of α-ENaC with a specific siRNA leads to a pronounced stimulation of the rate of apoptosis (n = 5 to 8, for each experimental condition; significantly different from control with *p < 0.05 and ***p < 0.001, respectively)