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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Nat Neurosci. 2008 Dec 21;12(1):60–69. doi: 10.1038/nn.2238

Figure 1.

Figure 1

Impaired behavior of Zürich I PrP−/− mice in the cookie finding test. (a) Trial 1 of the cookie finding test for B6129 (filled dots) and ZI PrP−/− (open dots). Each dot represents a single individual. Individuals that failed the trial were assigned the conservative score of 600 s, corresponding to the total test time. Black lines represent medians. (b) Trial 2. Note that trial times were reduced to 5 min. Individuals that failed Trial 2 were given the conservative score of 300 s. (c) Schematic diagram of the genetic makeup of the B6129 WTs and ZI PrP−/− mice on a mixed B6 and 129 background. Red cross represents the knockout allele of Prnp. Black represents alleles of B6 origin; cyan represents alleles of 129 origin. (d) Individual progression of each B6129 mouse from Trial 1 to Trial 2. (e) Individual progression from Trial 1 to Trial 2 of each ZI PrP−/− mouse, excluding animals that failed Trial 1 or that found the cookie in Trial 1 with a latency>300 s and also failed Trial 2. n is indicated for points that overlap exactly. (f) Average degree of improvement for WT (filled circles) and knockout (open circles), calculated as Σ(T1/T2)/n, excluding animals that failed to find the cookie in Trial 1, or that found the cookie in Trial 1 with a latency>300 s and also failed Trial 2; error bars represent ±SEM.

In (a-b) *** p<0.001, two-tailed Mann Whitney test; in (f) * p<0.05 one-tailed unpaired t test.