Figure 6.

Power of LFPs and duration of the odor response in PrP^−/− mice. (a) Local Field Potentials (LFPs) were measured in vivo from the granule cell layer in the main olfactory bulb of anesthetized mice. (b) Example LFP traces from a B6129 mouse (top) and PrP^−/− mouse (bottom) with corresponding breathing traces. Odor presentation is triggered by the first inhalation/exhalation transition (I/E; black dot in left inset), but the odor is not detected until the following inhalation. Right inset: example of gamma range oscillations. (c) Average power spectra of a non-odor breath from wild type (B6129, n=11) PrP knockout (PrP^−/−, n=10), and neuronal PrP-expressing transgenic (NSE-PrP, n=5) mice. The power of high-gamma oscillations is significantly lower in PrP knockouts compared to both control strains. (d) In an odor containing breath, the power of all frequencies increased in all groups. (e) The power of gamma oscillations within each breath is plotted for 30 breaths around a two second pulse of amyl acetate. PrP^−/− animals have an extended oscillatory response to odor in the gamma frequency band as indicated by the time (in number of breaths) for the response to decay to 90% of its peak. (f) High-gamma oscillations in the PrP knockout also show a significantly longer decay compared to both control strains.

* p<0.05 using one-way ANOVA with post-hoc PLSD.