Table 1.

Mouse strains tested for cookie finding behavior. Abbreviations: ZI – Zürich I; PrP^−/− – PrP knockout; NSE – neuron specific enolase; MBP – myelin basic protein; lck - lymphocyte protein tyrosine kinase; CNS – central nervous system; PNS – peripheral nervous system.

All knockout and transgenic animals presented in this table are on the Zürich I mixed B6 and 129 genetic background. Critically, the transgenic lines had been generated by microinjection of PrP transgenes into homozygous Zürich I PrP^−/− zygotes, thus enabling direct comparisons between the different lines.

Strain name	Abbreviation	Type	Description	Reference	Genetic background	PrPc expression
C57BL/6J × 129/Sv F1 hybrid	B6129	WT	wild type hybrid	see Methods section, under Animals	50% C57BL/6J, 50% 129S/Sv	wild type
Zürich I PrP knockout	ZI knockout	KO	Prnp knockout	Büeler et al.; 19921	C57BL/6J × 129/Sv mixed background	none
Nagasaki PrP knockout	Ng knockout	KO	Prnp knockout with late-onset ataxia due to upregulation of Prnd	Sakaguchi et al.; 199644	congenic C57BL/6J	none
Edinburgh PrP knockout	Ed knockout	KO	Prnp knockout	Manson etal.; 199438	isogenic 129/Ola	none
Tg20	Tg20	Tg	Prnp driven by endogenous Prnp promoter (“half-genomic construct”)	Fischer et al.; 199845	ZI PrP−/− background	overexpression in wild-type locations
NSE-PrP	NSE-PrP	Tg	Prnp driven by NSE promoter	Radovanovic et al.; 200546	ZI PrP−/− background	neurons only (CNS and PNS)
MBP-PrP	MBP-PrP	Tg	Prnp driven by MBP promoter	Prinzetal.; 200447	ZI PrP−/− background	oligodendrocytes & Schwann cells only
Tg306	CD19-PrP	Tg	Prnp driven by CD 19 promoter	Montrasio etal.; 200148	ZI PrP−/− background	B cells only
Tg33	Lck-PrP	Tg	Prnp driven by Lck promoter	Raeberetal.; 199949	ZI PrP−/− background	T cells and some neurons
Prn knockout	Prn−/−	KO	double knockout of Prnp and homologous downstream gene Prnd	Genoud etal.; 200450	C57BL/6J × 129/Sv mixed background	none