Figure 1.

Ah −/− mice have smaller hepatocytes than wild-type mice. Livers of 1-year-old mice were fixed in formalin, and 6-μm sections were examined after staining with hematoxylin/eosin. (A and B) Thin sections from wild-type (A) and age-matched Ah knockout (B) mice are shown, and results of morphometric analyses follow. (C) There is a significant decrease in the total area of the hepatocytes of Ah −/− mice. (D and E) Whereas the cytoplasmic area of Ah −/− hepatocytes is significantly decreased (D), the nuclear areas of Ah +/+ and Ah −/− hepatocytes are not different (E). Mean and standard errors generated from comparison of six 1-year-old male Ah +/+ and six age- and sex-matched Ah −/− mice are shown; asterisks indicate significance (P < 0.05).