Figure 2.

(A) Livers of Ah −/− mice exhibit portosystemic shunting. With perfusion of colloidal carbon, livers of Ah +/+ mice become black (Left), whereas livers of Ah −/− mice remained pink (Right). The livers of male mice are shown above the livers of female mice. The figure represents livers of five male and five female mice from each group. (B) In Ah −/− mice, microspheres bypass liver sinusoids. The hepatic portal veins of six Ah +/+ and 6 Ah −/− mice were injected with microspheres and then livers and lungs were removed. The extent of portosystemic shunting was calculated as the number of microspheres found in lung divided by the number of microspheres found in both the lung and the liver. Mean and standard errors are shown; asterisks indicate significance (P < 0.05).