Figure 2.

The MLL complex. After post-transcriptional proteolytic processing amino-terminal and carboxy-terminal portions of MLL are incorporated in a macromolecular complex with histone methyltransferase and histone acetyltransferase function. Functional domains in MLL are indicated in yellow. AT = AT-hooks, a DNA binding domain, CxxC = motif recognizing unmethylated CpG dinucleotides, PHD = plant homeodomain, SET = histone methyltransferase active site. Proteins associated with MLL are explained in the text.