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Anti-Dsg1 IgG4 antibodies from FS patients are pathogenic in neonatal mice. IgG4 purified from FS patients was injected intraperitoneally to neonatal Blab/c mice. (a) In the course of 8–24 hours, these animals develop superficial vesicles and erosions. (b) Histologic examination reveals subcorneal vesicles and (c) direct IF shows the human IgG4 bound to the epidermal intercellular spaces.
