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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: J Autoimmun. 2008 Oct 5;31(4):311–324. doi: 10.1016/j.jaut.2008.08.003

Figure 6.

Figure 6

Rationale of pemphigus therapies. The five targeted areas where immuno-intervention may play a role in controlling disease activity in PV, PF and FS are shown in this figure. A PV patient is depicted with the targeted sites: (1) elimination of the autoantigen or triggering environmental antigen, (2) deletion of autoreactive and regulatory T cell activation, (3) deletion of autoreactive B cell responses, (4) elimination of circulating autoantibody and (5) altering the keratinocyte responses to pathogenic autoantibodies (epidermis becomes “resistant” to these autoantibodies).