Skip to main content
. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Immunol. 2009 May 1;182(9):5203–5207. doi: 10.4049/jimmunol.0804243

Figure 3. Blocking CD59 on CD4+ T cells increases the immune response.

Figure 3

(A) Proliferation of CD4+ T cells stimulated with anti-CD3 antibodies in the presence of irradiated PBMCs as APCs and Fab fragments of antibodies to CD59 (HC-1 or MEM-43) or control Fab fragments. (B) Proliferation of CFSE labeled CD4+ T cells when stimulated with anti-CD3 antibodies in the presence of irradiated PBMCs as APC and either HC-1 or MEM-43 Fab fragments. Values (mean of triplicates) in the histograms indicate the mitotic divisions under the respective conditions. (C) Proliferation of CD4+ T cells stimulated with anti-CD3 antibodies in the presence of irradiated CD59-ve U937 cells and either HC-1 or MEM-43 Fab fragments. (D) Proliferation of CD4+ T cells stimulated with anti-CD3 antibodies and cross-linked anti-CD59 antibodies. Statistical significance (* = p< 0.05) was evaluated using the Student's t test. The results are representative of four independent experiments performed using blood obtained from different individuals.

HHS Vulnerability Disclosure