Figure 5. Blocking CD59 increases the IFN-γ response to tumour antigens in CRC patients.
IFN-γ production in response to tumor antigens CEA (A) and 5T4 (B) in the presence and absence of Fab fragments of antibodies to CD59. The results are representative of three independent experiments with blood obtained from different individuals. (C) IFN-γ response to tumor antigens in PBMCs depleted and undepleted for CD4+CD25hi cells in the presence and absence of Fab fragments of antibodies to CD59. Statistical significance (* = p< 0.05, ** = p < 0.01) was evaluated using the Student's t test.