Table 2. Summary of Toxicities in > 10% of Subjects or Any Grade 3 or 4 Toxicities.

Toxicity	Any Grade n, (%)	Grade 3 or 4 n, (%)	At Baseline n, (%)
Constitutional
Fatigue	10 (50)	2 (10)	6 (30)
Sweating	4 (20)		3 (15)
Anorexia	4 (20)		2 (10)
Insomnia	4 (20)		1 (5)
Dermatologic
Skin disorder	5 (25)		2 (10)
Skin infection	1 (5)	1 (5)
Gastroenterology
Constipation	6 (30)		2 (10)
Nausea	6 (30)		1 (5)
Diarrhea	4 (20)		1 (5)
Vomiting	3 (15)		1 (5)
Hematologic
Low hemoglobin	16 (80)		12 (60)
Lymphopenia	9 (45)		3 (15)
Leukopenia	5 (25)
Low ANC	2 (10)	1 (5)
Hepatic
High ALT/AST	6 (30)		4 (20)
High alkaline phosphatase	5 (25)		2 (10)
Metabolic
High glucose	10 (50)		4 (20)
Low glucose	3 (15)		2 (10)
Low albumin	7 (35)		4
Neurological
Headache	5 (25)
Peripheral neuropathy	5 (25)		4 (20)
Dizziness	3 (15)	1 (5)
Pain
Extremity/joint pain	7 (35)		1 (5)
Other pain	7 (35)		3 (15)
Pulmonary
Dyspnea	9 (45)	3 (15)	2 (10)
Cough	7 (35)
Renal/Electrolytes
High creatinine	14 (70)		5 (25)
High potassium	5 (25)		4 (20)
High calcium	3 (15)		2 (10)
High uric acid	3 (15)	1 (5)	1 (5)
Low sodium	3 (15)
Low magnesium	3 (15)		3 (15)
Hypertension	3 (15)	1 (5)	2 (10)
Fracture	1 (5)	1 (5)

Abbreviations: ALT = alanine aminotransferase; ANC = absolute neutrophil count; AST = aspartate aminotransferase