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. 2009 Jul 1;23(13):1571–1585. doi: 10.1101/gad.1806309

Figure 3.

Figure 3.

Tcf4 (Tcf7l2) is expressed in oligodendrocyte lineage during developmental myelination. (A) Tcf4 labels a subset of Olig2 cells at P1 and P15 during developmental myelination of spinal cord white matter. (B) At P1, Olig1 protein is almost entirely nuclear (which we showed previously is a marker for OLPs) (Kitada and Rowitch 2006), and Tcf4 is expressed in a subset of these cells. (C) Tcf4 protein does not colocalize with cytoplasmic Olig1 protein (which we showed previously marks mature oligodendrocytes) (Kitada and Rowitch 2006) at P9. (D) Tcf4 colocalizes with OLP marker PDGFRα protein at P5 but does not colocalize with mature oligodendrocyte marker PLP message at P5 or P9.