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. 2009 Jul 1;23(13):1571–1585. doi: 10.1101/gad.1806309

Figure 8.

Figure 8.

Scheme indicating expression of Tcf4 proteins and effects of Wnt–β-catenin signaling to inhibit the transition from premyelinating to mature oligodendrocyte. Our genetic evidence is consistent with APC (CC1, a known marker of mature oligodendrocytes) acting to promote differentiation. HYCCIN, a Wnt-repressed target (Kawasoe et al. 2000) with essential roles in human myelination (Zara et al. 2006), is expressed in rodent oligodendrocytes and down-regulated in Olig2cre/DA-Cat mice (Supplemental Fig. 8). Temporal expression of Tcf4 and markers of oligodendrocyte lineage tested in this study is shown. (Pre OL) Premyelinating oligodendrocyte; (OL) oligodendrocyte.