Table 1.
Genotype analysis of progeny from p38α heterozygous intercrosses
| Age | Genotype
|
||
|---|---|---|---|
| Wild type | Heterozygous | Homozygous mutant | |
| 8.5 dpc | 4 | 4 | 2 |
| 9.5 dpc | 14 | 16 | 7 |
| 10.5 dpc | 28 | 69 | 25 (1/25 inviable) |
| 11.5 dpc | 17 | 31 | 9 (8/9 inviable) |
| 12.5 dpc | 11 | 16 | 8 (6/8 inviable) |
| 13.5 dpc | 6 | 14 | 5 (4/5 inviable) |
| 15.5–16.5 dpc | 6 | 6 | 3 (3/3 inviable) |
| Postnatal (129Sv × C57B1/6) | 117 | 204 | 0 |
| Postnatal (129Sv × BlkSw) | 18 | 15 | 0 |
| Postnatal (129Sv × Sw) | 22 | 17 | 0 |
| Postnatal (129Sv × BALB/c) | 21 | 10 | 0 |
Genotyped embryos that were severely retarded or in the process of resorbing were scored as inviable. Embryonic analyses were performed with 129Sv × C57B1/6 F2 embryos. Postnatal mice were scored at 3 wk of age.