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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Eur J Neurosci. 2008 Oct;28(8):1557–1568. doi: 10.1111/j.1460-9568.2008.06456.x

FIG. 3.

FIG. 3

Immunohistochemical localization of tyrosine hydroxylase (TH) in the dorsolateral and ventromedial striatum of young and aged wild-type (WT) and GFRα-1+/− mice. Insets show the magnified view of the dorsal striatum from the respective images, and the boxed area shows the ventromedial striatum (scale bar 125 µm, inset scale bar 10 µm). TH-positive fiber density in the dorsolateral striatum and the shell of the ventromedial striatum did not vary according to genotype or the ages examined. However, the core of the ventromedial striatum of the aged GFRα-1+/− mice exhibited a significant increase (*P < 0.05) in TH-positive fiber density as compared to all other groups.