Table 2.
Minor allele frequencies and Hardy Weinberg-Equilibrium p-values for the genetic polymorphisms among women without migraine in the Women’s Health Study (N=21,008)
| Gene | Symbol | Polymorphism | Chromosome | MAF | HWE* |
|---|---|---|---|---|---|
| Adducin 1 (alpha) | ADD1 | rs4961 | 4p16.3 | 0.194 | 0.473 |
| Angiotensin II receptor type 1 | AGTR1 | rs5186 | 3q21-25 | 0.304 | 0.7485 |
| Angiotensinogen | AGT | rs699 | 1q42-43 | 0.416 | 0.411 |
| Angiotensin-converting enzyme 1 | ACE | rs1799752 | 17q23 | 0.477 | <0.0001 |
| Beta-2 adrenergic receptor | ADRB2 | rs1042713 | 5q31-32 | 0.369 | 0.51 |
| rs1042714 | 0.435 | 0.1425 | |||
| rs1800888 | 0.014 | 0.0205 | |||
| Beta-3 guanine nucleotide-binding protein | GNB3 | rs5443 | 12p13 | 0.306 | 0.479 |
| CD14 molecule | CD14 | rs2569190 | 5q31.1 | 0.475 | 0.275 |
| Chemokine receptor 2 | CCR2 | rs1799864 | 3p21 | 0.086 | 0.289 |
| Chemokine receptor 3 | CCR3 | rs5742906 | 3p21.3 | 0.003 | 1 |
| Chemokine receptor 5 | CCR5 | rs333 | 3p21 | 0.104 | <0.0001 |
| rs1799987 | 0.446 | 0.6105 | |||
| Chemokine ligand 11 | CCL11 | rs3744508 | 7q21.1-21.2 | 0.176 | 0.2275 |
| rs4795895 | 0.189 | 0.8865 | |||
| Chemokine ligand 12 | CXCL12 | rs1801157 | 10q11.1 | 0.197 | 0.559 |
| Coagulation factor II | F2 | rs1799963 | 11p11-q12 | 0.014 | 0.015 |
| Coagulation factor V | F5 | rs6025 | 1q23 | 0.027 | 0.5075 |
| Coagulation factor VII | F7 | rs5742910 | 13q34 | 0.119 | 0.9705 |
| rs6046 | 0.109 | 0.917 | |||
| Colony stimulating factor 2 | CSF2 | rs25882 | 5q31.1 | 0.199 | <0.0001 |
| Complement component 3 | C3 | rs2230199 | 19p13.3-p13.2 | 0.209 | 0.0045 |
| Complement component 5 | C5 | rs17611 | 9q33-q34 | 0.438 | 0.1615 |
| Cystathionine-beta-synthase | CBS | rs12329790 | 21q22.3 | 0.002 | 1 |
| Cytotoxic T-lymphocyte-associated protein 4 | CTLA4 | rs5742909 | 2q33 | 0.094 | 0.9625 |
| rs231775 | 0.381 | 0.882 | |||
| Fibrinogen beta | FGB | rs1800790 | 4q28 | 0.213 | <0.0001 |
| Group-specific component (vitamin D binding protein) | GC | rs7041 | 4q12-q13 | 0.437 | 0.0705 |
| rs4588 | 0.284 | 0.1325 | |||
| Integrin, alpha 2 | ITGA2 | rs1062535 | 5q23-31 | 0.396 | 0.7 |
| Integrin, beta3 | ITGB3 | rs5918 | 17q21.32 | 0.153 | 0.184 |
| Intercellular adhesion molecule 1 | ICAM1 | rs5491 | 19p13.3-13.2 | 0.003 | 1 |
| rs1799969 | 0.116 | 0.918 | |||
| Interleukin 1 alpha | IL1A | rs1800587 | 2q14 | 0.299 | 0.1815 |
| Interleukin 1 beta | IL1B | rs16944 | 2q14 | 0.330 | 0.8035 |
| rs1143634 | 0.232 | 0.8025 | |||
| Interleukin 4 | IL4 | rs2243250 | 5q31.1 | 0.151 | 0.4905 |
| Interleukin 4 receptor | IL4R | rs1805010 | 16p11.2-12.1 | 0.450 | 0.9665 |
| rs1805015 | 0.164 | 0.485 | |||
| rs1801275 | 0.207 | 0.6415 | |||
| Interleukin 5 receptor, alpha | IL5RA | rs2290608 | 3p26-24 | 0.256 | 0.6535 |
| Interleukin 6 | IL6 | rs1800796 | 7p21 | 0.053 | 0.155 |
| rs1800795 | 0.422 | 0.358 | |||
| Interleukin 9 | IL9 | rs2069885 | 5q31.1 | 0.133 | 0.4655 |
| Interleukin 10 | IL10 | rs1800872 | 1q31-32 | 0.230 | 0.454 |
| Interleukin 13 | IL13 | rs1295686 | 5q31 | 0.203 | 0.6385 |
| Leukotriene C4 synthase | LTC4S | rs730012 | 5q35 | 0.285 | 0.87 |
| Lymphotoxin alpha | LTA | rs1041981 | 6p21.3 | 0.343 | 0.157 |
| rs909253 | 0.337 | 0.5555 | |||
| Matrix metallopeptidase 3 | MMP3 | rs3025058 | 11q22.3 | 0.489 | 0.008 |
| Membrane-spanning 4-domains, subfamily A, member 2 | MS4A2 | rs569108 | 11q13 | 0.026 | <0.0001 |
| 5,10-methylenetetrahydrofolate reductase | MTHFR | rs1801133 | 1p36.3 | 0.332 | 0.0465 |
| Natriuretic peptide precursor A | NPPA | rs5063 | 1p36.21 | 0.050 | 0.2285 |
| rs5065 | 0.147 | 0.7865 | |||
| Nitric oxide synthase 2A | NOS2A | rs1137933 | 17q11.2-q12 | 0.224 | 0.4825 |
| Nitric oxide synthase 3 | NOS3 | rs1800779 | 7q36 | 0.374 | 0.098 |
| rs3918226 | 0.081 | 0.33 | |||
| rs1799983 | 0.327 | 0.651 | |||
| Secretoglobin, family 1A, member 1 | SCGB1A1 | rs3741240 | 11q12.3-13.1 | 0.351 | 0.278 |
| Selectin E | SELE | rs5361 | 1q22-25 | 0.105 | 0.4835 |
| rs5355 | 0.041 | 0.9235 | |||
| Selectin P | SELP | rs6131 | 1q22-25 | 0.187 | 0.1585 |
| rs6133 | 0.117 | 0.399 | |||
| Serpin peptidase inhibitor, clade E, member 1 | SERPINE1 | rs1799768 | 7q21.3-22 | 0.457 | 0.28 |
| rs7242 | 0.437 | 1 | |||
| Sodium channel, nonvoltage-gated 1 alpha | SCNN1A | rs5742912 | 12p13 | 0.023 | 0.8805 |
| rs2228576 | 0.331 | 0.5065 | |||
| Transcription factor 7 | TCF7 | rs5742913 | 5q31.1 | 0.105 | 0.388 |
| rs244656 | 0.136 | 0.36 | |||
| Transforming growth factor, beta 1 | TGFB1 | rs1800469 | 19q13.1 | 0.304 | 0.5275 |
| Tumor necrosis factor | TNF | rs1800750 | 6p21.3 | 0.014 | 0.001 |
| rs1800629 | 0.173 | 0.556 | |||
| rs673 | 0.003 | <0.0001 | |||
| rs361525 | 0.051 | 0.005 | |||
| Vascular cell adhesion molecule 1 | VCAM1 | rs1041163 | 1p32-31 | 0.160 | 0.9415 |
| Vitamin D (1,25-dihydroxyvitamin D3) receptor | VDR | rs2228570 | 12q13.11 | 0.388 | 0.284 |
| rs1544410 | 0.406 | 0.604 |
MAF: minor allele frequencies in decimals.
HWE: p-value from Fisher’s Exact test for Hardy Weinberg-Equilibrium