TABLE 1.
PK parameters of orbifloxacin after a single i.v. and i.m. injection at a dose of 2.5 mg/kg to beagle dogsa
| Parameterb | Orbifloxacin injection via:
|
|
|---|---|---|
| i.v. route | i.m. route | |
| Tmax (h) | 1.15 ± 0.37 | |
| Cmax (μg/ml) | 1.15 ± 0.14 | |
| AUC0-24 (μg·h/ml) | 8.07 ± 0.69 | 8.37 ± 0.94 |
| AUC0-∞ (μg·h/ml) | 8.21 ± 0.6 | 8.49 ± 0.93 |
| λz (1/h) | 0.17 ± 0.01 | 0.17 ± 0.01 |
| t1/2 λz (h) | 4.23 ± 0.2 | 3.95 ± 0.15 |
| MRT0-24 (h) | 4.71 ± 0.13 | 5.31 ± 0.17 |
| MRT0-∞ (h) | 5.13 ± 0.13 | 5.69 ± 0.11 |
| Vλz (liters/kg) | 1.95 ± 0.23 | |
| Vss (liters/kg) | 1.61 ± 0.13 | |
| CL (liters/kg/h) | 0.31 ± 0.03 | |
| MAT (h) | 0.51 ± 0.15 | |
| F (%) | 100.1 ± 4.76 | |
a
Values are means ± standard errors of the means; n = 6 beagle dogs.
b
Tmax, time of maximum observed concentration; λz, first-order rate constant associated with the terminal portion of the curve; t1/2 λz, terminal half-life; Vλz, apparent volume of distribution; Vss, volume of distribution at steady state; CL, total body clearance; F, bioavailability.