TABLE 2.
PD predictors of antimicrobial activity based on in vitro data, following i.m. and i.v. administration of 2.5 mg/kg orbifloxacin to beagle dogs
| Clinical isolate | PD predictors used for determination of antimicrobial activitya
|
||||
|---|---|---|---|---|---|
| AUC0-24/MIC (h)
|
T > MIC (h)
|
Cmax/MIC
|
|||
| i.v. route | i.m. route | i.v. route | i.m. route | i.m. route | |
| E. coli | 134.6 ± 11.5 | 129.8 ± 16.1 | 21.1 ± 0.25 | 21.3 ± 0.54 | 19.1 ± 1.9 |
| S. aureus | 32.3 ± 2.7 | 31.1 ± 3.9 | 8.75 ± 0.53 | 9.15 ± 0.55 | 4.61 ± 0.46 |
| S. intermedius | 32.3 ± 2.7 | 31.1 ± 3.9 | 8.75 ± 0.53 | 9.15 ± 0.55 | 4.61 ± 0.46 |
| P. mirabilis | 16.1 ± 1.3 | 15.5 ± 1.9 | 5.6 ± 0.47 | 6.5 ± 0.41 | 2.3 ± 0.23 |
a
Values are means ± standard errors of the means; n = 6 beagle dogs.