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Molecular surfaces of the ribosomal A site (A) (28) and APH(3′)-IIIa around the amikacin-binding site (B). Amikacin is shown in yellow sticks, and the green sphere represents the bulky group that could be added to replace the carbonyl of the AHB tail. An appropriate substitution at this location should not interfere with the binding of the aminoglycoside derivative to the A site. However, such an addition would not be accommodated by the APH(3′)-IIIa resistance enzyme.
