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. 2009 May 4;53(7):3003–3009. doi: 10.1128/AAC.01584-08

FIG. 2.

FIG. 2.

Impact of plectasin derivative NZ2114 dose escalation on burden of either S. pneumoniae or S. aureus in the thighs of neutropenic mice over time. Each symbol represents the mean CFU/thigh from two mice (four thighs). The error bars represent the standard deviations. Solid symbols represent growth of organisms in control mice over time. Open symbols represent the burden of organisms in NZ2114-treated mice. The horizontal boxes represent the duration of time that free drug NZ2114 serum concentrations remained above the MIC of the infecting organism. The PAE is expressed in hours.