TABLE 1.
Noncompartmental pharmacokinetic analysis
| PK parametera | Value for the parameter (mean ± SD) in:b
|
|||
|---|---|---|---|---|
| Plasma (total drug) | Plasma (free drug) | s.c. adipose tissue | Muscle | |
| Cmax (mg/liter) | 25.8 ± 2.96 | 20.2 ± 2.63 | 9.61 ± 4.74 | 14.0 ± 3.22 |
| Tmax (mg/liter) | 1.92 ± 0.15 | ND | 2.25 ± 0.21 | 2.25 ± 0.14 |
| t1/2 (h) | 2.61 ± 0.33 | ND | 2.56 ± 0.39 | 2.61 ± 0.52 |
| AUC0-last (h·mg/liter) | 97.1 ± 10.3 | 76.0 ± 8.81 | 34.3 ± 19.0 | 50.6 ± 10.9 |
| AUC0-∞ (h·mg/liter) | 98.0 ± 10.5 | 76.9 ± 8.94 | 36.5 ± 19.4 | 53.2 ± 11.5 |
| CL (liter/h) | 5.15 ± 0.53 | ND | ND | ND |
| Vz (liters) | 19.4 ± 3.61 | ND | ND | ND |
| Vss (liters) | 14.6 ± 2.17 | ND | ND | ND |
| AUCISF/fAUCplasma | 0.49 ± 0.28 | 0.69 ± 0.13 | ||
a
t1/2, half-life; CL, clearance; Vz, apparent volume of distribution.
b
ND, not determined.