TABLE 2.
Parameter | Mean AUC (mg·h/liter) for the indicated drug (dosing regimen)
|
|||||||
---|---|---|---|---|---|---|---|---|
Cefpodoxime (400 mg orally)a | Cefixime (400 mg orally)a | Cefpirome (2 g i.v. in 15 min)b | Cefpirome (2 g i.v. in 10 min)c | Cefpirome (2 g i.v. in 8 h)d | Cefaclor (500 mg of IR orally)e | Cefaclor (500 mg of MR orally)f | Cefaclor (750 mg of MR orally)f | |
AUCplasma | 22.4 | 25.6 | 17.6 | 13.7 | 22.1 | |||
fAUCplasma | 17.7 | 9.0 | 275.0 | 230.7 | 175.0 | 13.2 | 10.3 | 16.6 |
fAUCmuscle | 15.4 | 7.3 | 130.0 | 80.0 | 9.49 | 7.02 | 11.53 | |
fAUCs.c.adipose | 218.5 | 117.0 | 87.2 | |||||
fAUCmuscle/fAUCplasma | 0.89 | 0.84 | 0.56 | 0.46 | 0.73 | 0.67 | 0.70 | |
fAUCs.c.adipose/fAUCplasma | 0.79 | 0.51 | 0.50 |
AUC0-∞ is presented. fAUC was calculated based on protein binding (14).
AUC0-4 is presented. Data are from healthy volunteers only (21).
AUC0-8 is presented (10).
Only 8 h was observed. AUC0-8 is presented (10).
AUC0-∞ is presented. fAUC was calculated based on protein binding (7). IR, immediate release.
AUC0-∞ is presented. fAUC was calculated based on protein binding (7). MR, maximum release.