TABLE 2.

Soft-tissue penetration of four cephalosporins determined by microdialysis

Parameter	Mean AUC (mg·h/liter) for the indicated drug (dosing regimen)
	Cefpodoxime (400 mg orally)a	Cefixime (400 mg orally)a	Cefpirome (2 g i.v. in 15 min)b	Cefpirome (2 g i.v. in 10 min)c	Cefpirome (2 g i.v. in 8 h)d	Cefaclor (500 mg of IR orally)e	Cefaclor (500 mg of MR orally)f	Cefaclor (750 mg of MR orally)f
AUCplasma	22.4	25.6				17.6	13.7	22.1
fAUCplasma	17.7	9.0	275.0	230.7	175.0	13.2	10.3	16.6
fAUCmuscle	15.4	7.3		130.0	80.0	9.49	7.02	11.53
fAUCs.c.adipose			218.5	117.0	87.2
fAUCmuscle/fAUCplasma	0.89	0.84		0.56	0.46	0.73	0.67	0.70
fAUCs.c.adipose/fAUCplasma			0.79	0.51	0.50

^aAUC_0-∞ is presented. fAUC was calculated based on protein binding (14).

^bAUC_0-4 is presented. Data are from healthy volunteers only (21).

^cAUC_0-8 is presented (10).

^dOnly 8 h was observed. AUC_0-8 is presented (10).

^eAUC_0-∞ is presented. fAUC was calculated based on protein binding (7). IR, immediate release.

^fAUC_0-∞ is presented. fAUC was calculated based on protein binding (7). MR, maximum release.