TABLE 4.
Pharmacokinetics of HDP-(S)-[8-14C]HPMPA after oral and intraperitoneal administration to micea
| Fluid or tissue | Orally administered HDP-(S)-[8-14C]HPMPA
|
Intraperitoneally administered HDP-(S)-[8-14C]HPMPA
|
||||
|---|---|---|---|---|---|---|
| Tmaxb (h) | Cmax (nmol/g)c | AUCd (nmol·h/g) | Tmax (h) | Cmax (nmol/g) | AUCd (nmol·h/g) | |
| Plasma | 1 | 1.11 | 12.1 | 3 | 2.23 | 16.4 |
| Liver | 3 | 21.1 | 222.2 | 1 | 131.5 | 545.1 |
| Kidney | 3 | 5.07 | 68.8 | 1 | 22.9 | 195.7 |
| Lung | 3 | 2.89 | 12.8 | 1 | 2.84 | 21.5 |
| Spleen | 3 | 0.22 | 3.90 | 1 | 1.58 | 16.3 |
| Heart | 1 | 0.20 | 2.69 | 1 | 0.57 | 3.80 |
| Brain | 3 | 0.07 | 0.68 | 1 | 0.16 | 0.98 |
a
An oral or intraperitoneal dose of 10 mg/kg was administered.
b
Tmax, time to Cmax.
c
For plasma, the units of Cmax are nanomoles/ml.
d
AUC from time zero to 24 h.