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Simulated clarithromycin concentration in the inhibition compartment (A) for the 500-mg b.i.d. dose and its autoinhibition effect with time (B). The value of the overall inhibition parameter is 100% if there is no inhibition, whereas maximal potential inhibition at high clarithromycin concentrations in the effect compartment would yield a value of 10% and would represent the noninhibitable fraction of CLp.
