TABLE 3.
Mean change in viremia and in CD4 cell counts from baseline to week 48 in patients treated with ENF according to the presence/absence of mutation E57Arev
| Amino acid at position 57 | Frequency (no. of positive patients [%])a | Viremia data
|
CD4 cell count data
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of RNA copies/ml at:
|
Mean change | P valueb | No. of cells/μl at:
|
Mean change | P valueb | ||||
| Baseline | Wk 48 | Baseline | Wk 48 | ||||||
| E57 wild type | 75 (85.2) | 4.9 | 4.4 | −0.84 | 0.006 | 146 | 192 | +56 | 0.04 |
| E57A | 13 (14.8) | 4.9 | 5.4 | +0.93 | 176 | 104 | −42 | ||
a
The frequency was determined in 88 ENF-treated patients.
b
Significance was determined for the mean change from baseline to week 48 in the presence versus the absence of the mutation (Mann-Whitney test).