TABLE 2.

Dose-response relationship of tigecycline against E. coli and K. pneumoniae test isolates in the neutropenic mouse thigh model

Isolatea	Efficacy of tigecycline as determined by:
	EI80 (fAUC/MIC)	EI50 (fAUC/MIC)	Static exposure (fAUC/MIC)	Maximum Δlog10 (CFU/ml)
EC 54	7.70	5.19	5.96	−2.05
EC 120	7.30	3.70	4.76	−2.30
EC 315b	4.46	3.71	3.88	−2.00
EC 321b	9.07	6.40	6.83	−2.54
EC 322b	10.64	6.27	7.50	−2.40
KP 134	10.04	5.91	6.53	−1.42
KP 135	7.78	3.62	5.40	−1.51
KP 255b	4.81	2.64	2.02	−3.15
KP 266b	7.15	5.37	5.13	−1.34
KP 320b	3.27	2.01	3.09	−1.12
KP 321c	7.48	4.53	5.47	−1.46
Mean (SD)	7.25 (2.30)	4.49 (1.47)	5.14 (1.64)	−1.93 (0.56)
Composite	8.40	4.74	5.32	−1.94

^aInternal strain designation.

^bESBL-producing isolate.

^cCarbapenemase-producing isolate.