FIG. 6.
Reductions of bacterial titers in the blood samples of mice inoculated with MRSA strain WHO-2 by anti-mecA encapsulated PS-ODN833. Mice were randomly chosen to receive, intravenously via the tail vein, isotonic sodium chloride solution (control group; C), 100 mg/kg oxacillin (Oxa; twice daily for 7 days), liposome-encapsulated PBS (L-PBS; once daily for 3 days) and 100 mg/kg oxacillin (twice daily for 7 days), 10 mg/kg free PS-ODN833 (F-ODN; once daily for 3 days) and 100 mg/kg oxacillin (twice daily for 7 days), or 2.5, 5, or 10 mg/kg liposome-encapsulated PS-ODN833 (L-ODN833; once daily for 3 days) and 100 mg/kg oxacillin (twice daily for 7 days). Horizontal lines represent the average CFU value in each group. *, P > 0.05; **, P < 0.05; and ***, P < 0.01 for comparison to control results.