FIG. 5.

Expression of ERG11, PDR12, CDR1, and CDR2 genes in C. glabrata clinical isolates 22852 (black bars) and 22853 (gray bars) relative to that in wild-type isolate 21231. Expression was determined by RT-PCR. Relative to the level of expression by the control, PDR1 and CDR1 were overexpressed in the two clinical isolates, CDR2 was underexpressed in hypersusceptible isolate 22852, and HSP12 was underexpressed in azole-resistant isolate 22853. The levels of expression of ERG11 were similar in the clinical isolates and the control. The data presented are mean values (± standard deviations) of the changes from four independent experiments.