TABLE 4.
Point mutations in ERG11 and PDR1 genes from C. glabrata isolates 22852 and 22853
| Gene | Point mutation in gene of isolatea:
|
|
|---|---|---|
| 22852 | 22853 | |
| ERG11 | T834C | T834C |
| T846C | T846C | |
| T1275C | T1275C | |
| PDR1 | G307A | G307A |
| T329C | T329C | |
| G763A | G763A | |
| G1699A | G1699A | |
| C1892T | C1892T | |
| G2219A | G2219A | |
a
Mutations are described as follows: the first letter indicates the nucleotide in the GenBank database sequence for the corresponding gene (GenBank accession numbers AY700584 for PDR1 and L40389 for ERG11), the number gives the position relative to the start of the open reading frame, and the second letter indicates the nucleotide found in the gene sequence of isolate 22852 or 22853. The nonsense mutation found in the PDR1 gene sequence is underlined. Other mutations are silent. The GenBank accession numbers of the sequences are indicated in Materials and Methods.