. Author manuscript; available in PMC: 2009 Jul 1.

Published in final edited form as: Clin Gastroenterol Hepatol. 2008 Apr 14;6(5):575–583. doi: 10.1016/j.cgh.2008.02.035

Table 2.

Peginterferon alfa-2a noncompartmental pharmacokinetic parameters

Parameter	AA (n = 40)	CA (n = 51)	p-value
Cmax (ng/mL)	12.0 (7.7, 16.0)	10.1 (6.6, 13.9)	0.18
Cmin (ng/mL)	6.8 (3.5, 8.9)	7.6 (4.6, 9.9)	0.55
Tmax (day)^*
1	2 (5.0)	7 (13.7)	0.045
2	13 (32.5)	12 (23.5)
3	22 (55.0)	19 (37.3)
7	3 (7.5)	13 (25.5)
AUC (ng^* hr/mL)	1413 (969, 1926)	1201 (759, 1738)	0.24
Accumulation ratio^**	3.3 (2.6, 4.9)	2.9 (2.2, 4.2)	0.23

Values are expressed as median (IQR)

P-values correspond to two-sample Wilcoxon rank tests for Cmax, Cmin, AUC, and Accumulation ratio.

Tmax values reported as n (%), p-value derived from Pearson’s chi-square test of association.

^**

Ratio of the week 24 and week 1 peginterferon Cmin values