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Overexpression of HIF-1α under normoxic conditions does not induce RTA. (A) Anti-HIF-1α Western blot of whole-cell lysates of JSC-1 and HBL-6 cells transduced with lentivirus expressing HIF-1α. (B) RTA Western blot of JSC-1 and HBL-6 cells untransduced (Neg) or transduced with empty vector (pIG), HIF-1α-expressing (pHIF-1αIG), and XBP-1s-expressing (pXBP-sIG) plasmids. RTA is induced only in the presence of XBP-1s expression (pXBP-sIG) under normoxic conditions.
