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. 2009 Jul 13;4(7):e6218. doi: 10.1371/journal.pone.0006218

Figure 1. Lifespan of littermates from the SOD1G93A x GarsC201R/ + cross.

Figure 1

(A) Male mice: SOD1G93A n = 13; SOD1G93A;GarsC201R/+ n = 10. (B) Female mice: SOD1G93A n = 11; SOD1G93A;GarsC201R/+ n = 10. Maximum body weights. Weights were recorded between 90 and 110 days which corresponds to the maximum body weight prior to weight loss as the disease progresses. (C) Males: wildtype 30.2±0.9 g (n = 13); SOD1G93A 25.1±0.4 g (n = 13); GarsC201R/+ 27.9±0.4 g (n = 12); SOD1G93A;GarsC201R/+ 24.9±0.6 g (n = 11). (D) Females: wildtype 22.6±0.4 g (n = 13); SOD1G93A 19.5±0.6 g (n = 12); GarsC201R/+ 20.3±0.3 g (n = 9); SOD1G93A;GarsC201R/+ 20.2±0.5 g (n = 11). (E) A representative western blot of human and mouse SOD1 using spinal cord homogenate from 4 month old mice; hSOD is human SOD1 protein. (F) Quantification of the human SOD1 protein levels in shows no transgene loss in SOD1G93A;GarsC201R/+ compared to SOD1G93A mice mice (n = 4 per cohort).