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Increased astrocytosis with disease progression in Cln5 deficient mice (A, B) Thresholding image analysis confirms the progressive and significant accumulation of GFAP staining in both the thalamus (VPM/VPL, A) and cortex (S1BF, B) of Cln5 deficient mice (Cln5-/-) with increased age, compared to age matched controls (+/+). (mean±SEM; * p<0.05; *** p<0.001; ANOVA with post-hoc Bonferroni analysis).
