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Legend: Sequence alignment of predicted helicase domains of FANCM and its sequence homologs. The seven motifs present in all superfamily II helicases are underlined, and the conserved residues are highlighted. The arrow indicates the conserved lysine (K117) in motif I that has been replaced by arginine in Flag-FANCIvl ATPase mutant. ERCC4/XPF and Mei9 (the Drosophila homolog of ERCC4/XPF) are included in the alignment.
