Table 2. Maximum IOP, Cup-Disc Ratio, MD, and PSD values among different groups of APOE, p53, and p21 genotypes.
| Gene | Genotype |
MD |
PSD |
Cup-disc ratio |
Maximum IOP (mmHg) |
|---|---|---|---|---|---|
| mean±SD (median) | mean±SD (median) | mean±SD (median) | mean±SD (median) | ||
|
APOE |
ε2/3 |
-9.00±8.00 (-4.72) |
5.47±4.51 (2.21) |
0.58±0.22
(0.6) |
27.36±4.38 (28.00) |
| ε2/4 |
-18.62 (-18.62) |
9.29
(9.29) |
0.8
(0.8) |
28.00 (28.00) |
|
| ε3/3 |
-10.41±7.85 (-7.41) |
5.40±4.06 (3.4) |
0.596±0.214 (0.5) |
27.01±3.49 (26.00) |
|
| ε3/4 |
-4.65±3.01 (-4.09) |
2.23±1.41 (1.77) |
0.51±0.18 (0.5) |
24.62±1.99 (24.00) |
|
| ε4/4 |
-4.29 (-4.29) |
2.62 (2.62) |
0.3 (0.3) |
24.00 (24.00) |
|
| p value |
0.09 |
0.06 |
0.5 |
0.1 |
|
|
P53 codon72 |
Arg/Arg |
-10.13±7.4 (-8.45) |
5.33±4.54 (2.45) |
0.56±0.21 (0.5) |
26.8±3.1 (25.5) |
| Arg/Pro |
-9.71±8.1 (-7.01) |
5.34±4.09 (3.4) |
0.60±0.22 (0.65) |
26.2±3.2 (25) |
|
| Pro/Pro |
-8.9±7.0 (-5.63) |
4.11±2.85 (2.12) |
0.56±0.21 (0.55) |
29±4.5 (28.5) |
|
| p value |
0.7 |
0.9 |
0.7 |
0.1 |
|
| P21 codon31 | Ser/Ser |
-9.69±7.17 (-7.28) |
5.25±4.16 (2.74) |
0.58±0.21 (0.6) |
26.91±3.53 (26.00) |
| Ser/Arg |
-9.13±9.21 (-4.97) |
4.58±3.61 (2.31) |
0.57±0.20 (0.5) |
26.56±3.59 (25.00) |
|
| Arg/Arg |
- |
- |
0.3 (0.3) |
22.00 (22.00) |
|
| p value | 0.4 | 0.8 | 0.9 | 0.7 |
Details of clinical features of 75 POAG patients and 119 unaffected controls for each genotype are shown in the table. IOP indicates maximum intraocular pressure; C/D indicates cup-disc ratio of optic nerve; MD and PSD indicate visual field indices and mean±SD (median) indicates standard deviation from the mean. There were no significant differences in maximum IOP, MD and PSD values among different groups of p53 and p21 genotypes. POAG subjects with ε2ε3 genotype had worse visual field defects and POAG subjects with ε3ε3 genotypes had worse MD and PSD values.