Table 1.
Selected ligands and expression profiles of the Dectin-1 cluster of C-type lectin receptors
| Official name | Alternate names | Cellular expression (human) | Exogenous ligands | Endogenous ligands | Cellular function |
|---|---|---|---|---|---|
| CLEC12A | MICL, DCAL2, CLL1, KLRL1 | Myeloid cells | ? | Yes but identity unknown | Inhibition |
| CLEC1B | CLEC-2 | Platelets Myeloid cells? | Rhodocytin, HIV | Podoplanin | Activation |
| CLEC12B | Macrophage antigen H | Macrophages | ? | ? | Inhibition |
| CLEC9A | DNGR1 | BDCA3+ DC, monocyte subsets, B-cells | ? | ? | Activation |
| CLEC1A | CLEC-1 | DC | ? | ? | ? |
| CLEC7A | Dectin-1 | Myeloid cells, T-cell subsets, B cells, mast cells, eosinophils | β-Glucan, Mycobacterial ligand | T-cells Apoptotic cells | Activation |
| CLEC8A | LOX-1 | Endothelium, smooth muscle, platelets, fibroblasts, macrophages | Gram-positive Gram-negative bacteria | ox-LDL modified lipoprotiens Aged/apoptotic cells Advanced glycation end-products HSP70 | Activation |
‘?’ refers to unknown data.