Table 4.
Two-year cumulative absolute risk of histologically-confirmed cervical intraepithelial neoplasia grade 3 or more severe (≥CIN3) as diagnosed by QC pathology for carcinogenic HPV detection by Linear Array vs. Hybrid Capture 2 referred into ALTS because of an ASCUS Pap. LA results were also stratified on HPV risk group, and hc2 results were stratified on log units of signal strength (RLU/CO), a semi-quantitative measure of viral load. Carc., positive for any carcinogenic HPV genotype other than HPV16 or HPV18; Non-carc., positive for any of non-carcinogenic HPV genotypes
| QC Pathology | |||
|---|---|---|---|
| N | N≥CIN3 | %≥CIN3 | |
| Linear Array | |||
| Carcinogenic HPV | |||
| Negative | 1,465 | 19 | 1.3% |
| Positive | 1,824 | 266 | 14.6% |
| total | 3,289 | 285 | 8.7% |
| HPV Risk Group | |||
| Negative | 1,030 | 11 | 1.1% |
| Non-Carc. | 435 | 8 | 1.8% |
| Carc. | 1,103 | 90 | 8.2% |
| HPV18 | 158 | 15 | 9.5% |
| HPV16 | 563 | 161 | 28.6% |
| total | 3,289 | 285 | 8.7% |
| Hybrid Capture 2 | |||
| Carcinogenic HPV | |||
| Negative | 1,540 | 21 | 11.4% |
| Positive | 1,749 | 264 | 15.1% |
| total | 3,289 | 285 | 8.7% |
| Semi-Quantitative Viral Load | |||
| 1-9.99 (RLU/CO) | 410 | 31 | 7.6% |
| 10-99.99 (RLU/CO) | 477 | 83 | 17.4% |
| 100-999.99 (RLU/CO) | 621 | 113 | 18.2% |
| 1000+(RLU/CO) | 241 | 37 | 15.4% |
| Total | 3,289 | 285 | 8.7% |