. Author manuscript; available in PMC: 2009 Jul 2.

Published in final edited form as: Proteomics Clin Appl. 2008 May 1;2(5):670–684. doi: 10.1002/prca.200780023

Table 2.

Increased PTM of selected proteins implicated in ALS

Proteins	Accession^a	Modification	Induction	Ref
Transcriptionally controlled tumor protein 1	6678437	Carbonylation	SOD1^G93A	[74]
Ubiquitin carboxyl-terminal hydrolase isozyme L1	18203410	Carbonylation	SOD1^G93A	[74]
α B crystalline	6753530	Carbonylation	SOD1^G93A	[74]
Dihydropyrimidinase- related protein (DRP-2)	94730376	HNE^b	SOD1^G93A	[75]
Hsp-70	124339826	HNE^b	SOD1^G93A	[75]
α Enolase	12963491	HNE^b	SOD1^G93A	[75]
Aconitase 2, mitochondrial	60391212	Nitration	SOD1^G93A	[76]
Actin	46397334	Nitration	SOD1^G93A	[76]
Adenylate kinase isoenzyme 1	13959400	Nitration	SOD1^G93A	[76]
ATP synthase subunit β, mitochondrial precursor	20455479	Nitration	SOD1^G93A	[76]
Carbonic anhydrase II	146345383	Nitration	SOD1^G93A	[76]
Creatine kinase, B chain	417208	Nitration	SOD1^G93A	[76]
Dihydropyrimidinase-related-2	94730376	Nitration	SOD1^G93A	[76]
Disulfide isomerase associated 3	112293264	Nitration	SOD1^G93A	[76]
α Enolase	13637776	Nitration	SOD1^G93A	[76]
Heat shock cognate 71 kDa	51702275	Nitration	SOD1^G93A	[76]
Heat shock protein 4	81903134	Nitration	SOD1^G93A	[76]
L-Lactate dehydrogenase B chain	126042	Nitration	SOD1^G93A	[76]
Phosphoglycerate mutase 1	20178035	Nitration	SOD1^G93A	[76]
Rho GDP dissociation inhibitor 1	21759130	Nitration	SOD1^G93A	[76]
Stress-induced phosphoprotein 1	54036445	Nitration	SOD1^G93A	[76]
Superoxide dismutase (Mn)	3041732	Nitration	SOD1^G93A	[76]
Adducin p120	66792810	Phosphorylation	SOD1^G93A	[77]
Adducin p80	31542111	Phosphorylation	SOD1^G93A	[77]
Glycogen synthase kinase 3 alpha p44	72384361	Phosphorylation	SOD1^G93A	[77]
Glycogen synthase kinase 3 beta p40	9790077	Phosphorylation	SOD1^G93A	[77]
Protein kinase C alpha/beta p83	6755078	Phosphorylation	SOD1^G93A	[77]
Protein kinase R p68	6755160	Phosphorylation	SOD1^G93A	[77]
S6 kinase p64	54036143	Phosphorylation	SOD1^G93A	[77]
Cu, Zn-superoxide dismutase	45597447	Carbonylation	SOD1^G93A	[74]
		Cys-146 to cysteic acid	Parkinson’s Disease, Alzheimer’s Disease	[47]
		Cys-111 to persulfide	Na₂S	[78]
		Trp-32 oxidation	H₂O₂/HCO₃⁻	[79]
		Nitration and/or Trp-32oxidation	Peroxynitrite/NaHCO₃	[80, 81]
		SOD1 cross-linked via disulfide bonds	fALS mice	[82]
		Oxidation of His48, Phe-20	Ascorbic acid/CuCl₂	[4]
		Oxidation of His-80 and 120	Ascorbic acid/CuCl₂	[83]
		Oxidation of His118	H₂O₂	[84]
		Dioxygenized His-46, Oxidized Pro-60 & Val-116, Val-117	H₂O₂	[85]

NCBI accession number.

4-Hydroxy-2-nonenal.