Fig. 4.

Pancreas; 2-year-old Gnptg^−/− mouse. In older mice, there is disorganization of the acinar architecture and diffuse marked cytoplasmic alteration and cytomegaly of acinar cells. The ballooning vacuolar inclusions efface the basal perinuclear basophilia and are associated with decreased size and number of apical zymogen granules. The pancreatic interstitium was expanded multifocally by clusters of large round-to-polygonal pale histiocytic cells. HE.