Table 2.

Serum lysosomal enzyme activities in Gnptg^−/− and Gnptab^−/− mice.^*

	Enzyme†
Genotype (No. of mice)	β- Hexosaminidase	α-Mannosidase	β-Mannosidase	β-Galactosidase	β-Glucuronidase
Wild-type (7)	311 ± 114	990 ± 328	156 ± 33	20 ± 8	34 ± 14
α,β-KO (5)	2,087 ± 318	40,073 ± 5181	1,464 ± 211	277 ± 65	382 ± 92
Fold Increase Over Normal	6.7-fold	40.5-fold	9.4-fold	13.9-fold	11.2-fold
γ-KO (5)	2,688 ± 878	16,313 ± 1351	1,826 ± 453	335 ± 122	86 ± 31
Fold Increase Over Normal	8.6-fold	16.5-fold	11.7-fold	16.8-fold	2.5-fold

^*Gnptg^−/− = γ-subunit deficient mice; Gnptab^−/− = α/β-subunit deficient mice; KO = knock-out.

^†Data are expressed as nmol/ml/hr.