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. Author manuscript; available in PMC: 2009 Jul 2.
Published in final edited form as: Oncogene. 2007 Oct 8;27(14):1971–1980. doi: 10.1038/sj.onc.1210839

Figure 7. Role of BRCA1 in the multiple spindle phenotype observed in MTA1-over expressing cells.

Figure 7

A, MCF7/MTA1 cells transfected with GFP vector or GFP-BRCA1 was assessed by immunofluorescence staining for GFP (green), α-tubulin (Magenta), pericentrin (red) and DAPI stained DNA (blue). MTA1 over expression led to an increase in the number of centrosomes; this phenotype was compromised, however, by the reintroduction of BRCA1, thus implicating BRCA1 repression in the centrosome amplification observed in MTA1-overexpressing cells. B, Bar chart showing quantified results.